Protein Details: Gap junction alpha-1 protein

Protein ID

ICDB_Pro_0309

Protein Name

Gap junction alpha-1 protein

Gene Name

Gja1; Cxn-43

Organism

Rattus norvegicus (Rat)

Length

382 amino acids

AlphaFoldDB

AF-P08050-F1-model_v4.pdb

Function

Sequence

MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCENVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDGVNVEMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSVFEVAFLLIQWYIYGFSLSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVKDRVKGRSDPYHATTGPLSPSKDCGSPKYAYFNGCSSPTAPLSPMSPPGYKLVTGDRNNSSCRNYNKQASEQNWANYSAEQNRMGQAGSTISNSHAQPFDFPDDNQNAKKVAAGHELQPLAIVDQRPSSRASSRASSRPRPDDLEI

PDB Structures

1R5S 2N8T 3CYY

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Detected in ventricle and atrium (at protein level)

DOI ID

10.1083/jcb.105.6.2621; 10.1152/ajpendo.1991.260.5.e787; 10.1101/gr.2596504; 10.1016/s0021-9258(18)88810-x; 10.1111/j.1432-1033.1991.tb21075.x; 10.1083/jcb.108.6.2241; 10.1016/0006-291x(91)91037-d; 10.1016/s0014-5793(02)03441-5; 10.1074/jbc.m404073200; 10.1074/jbc.m403952200; 10.1007/s10858-010-9397-9; 10.1038/ncomms1812; 10.1038/ncomms1871; 10.1074/jbc.m113.533265; 10.1016/0022-2836(92)90253-g; 10.1074/jbc.m409552200; 10.1038/emboj.2008.138

RefSeq

NP_036699.1